Schematic representation of activated and inhibited Wnt/β-catenin pathway. “WNT ON point out?? On ligation of Wnts to their receptors composed of frizzled proteins and LRP5/6, the cytoplasmic protein DVL is activated and induces the suppression of GSK3β. Subsequently, stabilized &bet
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The Aβ removing is mainly liver-situated in the plasma, and over 90% Aβ is excreted to the bile by liver cells (Sehgal et al.
over aβ metabolism and aggregation seems to become most pronounced during the initiation stage of Aβ dyshomeostasis [57]. Escalating age exacerbates th